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Cataplexy meaning9/19/2023 ![]() Cvetkovic-Lopes V, Bayer L, Dorsaz S, Maret S, Pradervand S, Dauvilliers Y,.For example, studies suggest that bacterial or viral infections such as strep throat (streptococcus), colds, and influenza may be involved in triggering narcolepsy in people who are at risk. Other genetic and environmental factors are also likely to influence a person's chances of developing this disorder. However, variations in these genes probably make only a small contribution to the overall risk of developing narcolepsy. Many of these genes are thought to play roles in immune system function. Variations in several additional genes have also been associated with narcolepsy. It is unclear how these genetic changes influence the risk of developing the condition. Most people with narcolepsy have the HLA-DQB1*06:02 variation, and many also have specific versions of other, closely related HLA genes. A variation of the HLA-DQB1 gene called HLA-DQB1*06:02 has been strongly associated with narcolepsy, particularly in people who also have cataplexy and a loss of hypocretins. The HLA-DQB1 gene has many different normal variations, allowing each person's immune system to react to a wide range of foreign proteins. The HLA complex helps the immune system distinguish the body's own proteins from proteins made by foreign invaders (such as viruses and bacteria). The HLA-DQB1 gene is part of a family of genes called the human leukocyte antigen (HLA) complex. The most well-studied of these genes is HLA-DQB1, which provides instructions for making part of a protein that plays an important role in the immune system. Researchers have identified changes in several genes that influence the risk of developing narcolepsy. It is unclear what triggers the death of hypocretin-producing neurons in people with narcolepsy, although evidence increasingly points to an abnormality of the immune system. In particular, hypocretins regulate the daily sleep-wake cycle. These cells normally produce chemicals called hypocretins (also known as orexins), which have many important functions in the body. In most cases of narcolepsy with cataplexy, and in some cases without cataplexy, sleep abnormalities result from a loss of particular brain cells (neurons) in a part of the brain called the hypothalamus. Narcolepsy probably results from a combination of genetic and environmental factors, some of which have been identified, but many of which remain unknown. ![]() Most of the signs and symptoms persist throughout life, although episodes of cataplexy may become less frequent with age and treatment. Some people with narcolepsy have all of the major features of the disorder, while others have only one or two. The combination of hallucinations, vivid dreams, and sleep paralysis is often frightening and unpleasant for affected individuals. Many people with narcolepsy also experience sleep paralysis, which is an inability to move or speak for a short period while falling asleep or awakening. Affected individuals often have realistic and distressing dreams, and they may act out their dreams by moving excessively or talking in their sleep. They often experience vivid hallucinations while falling asleep (hypnogogic hallucinations) or while waking up (hypnopompic hallucinations). Most affected individuals have trouble sleeping for more than a few hours at night. However, some do not, which has led researchers to distinguish two major forms of the condition: narcolepsy with cataplexy and narcolepsy without cataplexy. Most people diagnosed with narcolepsy also have cataplexy. Episodes of cataplexy usually last just a few seconds, and they may occur from several times a day to a few times a year. These episodes of muscle weakness can cause an affected person to slump over or fall, which occasionally leads to injury. They last from a few seconds to a few minutes and often lead to a longer nap, after which affected individuals wake up feeling refreshed.Īnother common feature of narcolepsy is cataplexy, which is a sudden loss of muscle tone in response to strong emotion (such as laughing, surprise, or anger). "Sleep attacks" can occur at unusual times, such as during a meal or in the middle of a conversation. ![]() Affected individuals feel tired during the day, and several times a day they may experience an overwhelming urge to sleep. Narcolepsy is characterized by excessive daytime sleepiness. Although this condition can appear at any age, it most often begins in adolescence. Narcolepsy is a chronic sleep disorder that disrupts the normal sleep-wake cycle. Failed calculus jokes9/19/2023 ![]() We will remove the jokes that doesn't bring joy to people's lives. Note: These jokes are supposed to be fun and make you laugh. However, if you feel that some are intrusive or offends you, or others, in any way, don't hesitate to contact us. Math dad jokes mix mathematics concepts and puns together in order to make your brain - and stomach - chuckle! Here's an impressive list of 123 math dad jokes that are guaranteed to leave you rolling on the floor with laughter. Why did you take off points for the question about finding a formula for dy/dx for the curve x 2 + y 2 = 16? I mean, sure, I didn’t actually write anything down, but I figured it was implicit.Math may not always be the most exciting subject, but with a touch of dad humor, it can become seriously entertaining. We thought somebody said “infinite sequins.” I’m sorry to say it, but you’ve got a huge concavity. If the best student in our class maintains an A, and the worst student manages to raise his grade until it’s also an A, wouldn’t you have to give the rest of us A’s, based on the squeeze theorem? You go through and clear away all the signs of your ex, until there’s nothing left but you. Remember, doing a u-substitution is like the aftermath of a break-up. Want to race? You can even have a head start. ![]() I realize it saves fence if you use the river as one border of your pasture, but aren’t you worried about us falling into the water? I’m not sure we can swim! It’s like you don’t even notice I’m there! And now you want help creating a mathematical model for the consequences of your irresponsibility? Here’s a consequence: You’re fired. I finally tracked you down! Don’t deny it: You’re my parents, aren’t you?įirst, you endanger everybody on this crew by pulling that ladder away from the wall at a constant velocity. What’s your problem? Integration is easy-here, I’ll show you. If acceleration is the derivative of velocity, and velocity is the derivative of position, then what is position the derivative of? Did I just blow your mind? Now I can’t finish a calculus test without whispering (and then screaming) “THE LIMIT DOES NOT EXIST.” Thanks a lot. You misunderstood me! When I called the behavior at that point “discontinuous,” I meant it like, “Dis be continuous, mon.” Heck, you might even call it “fundamental.” To answer your question: Yes, I would say that the Fundamental Theorem of Calculus is something you should know for this calculus course. Whenever I feel down about myself, I just look at you and I think, “Hey, at least I’m not that guy.” So thanks for being the lowest of the low! I know you called this unit Optimization, but I’m feeling more like Pessimization right now. You guys are like snowflakes-each of you is totally unique! And if there are enough of you, it’s safer to call off school and stay home. You call yourselves “series”? You’re finite! What fun is that? Big Shot, huh? You are just a mid-sized fish in a very big pond, my friend. ![]() Please, show mercy! I beg you, have a heart! ![]() How does it feel to know you’re not complete? How does it feel to know you’re not special? I’ll put it this way: You don’t seem to understand me yet, but you keep getting closer. But hey, silver lining: you’re so far into the area below the curve that you’re practically an integral. I know it stings to fail a test that badly. You already get credit for the laws of motion, that cool apple story, and the tasty fig cookies. ![]() Double-click any blank space on your desktop and your desktop icons will fade out. Quickly personalize the labels, background colors, and transparency of your fences from the easy-to-use configuration menu. For example, your documents or pictures folders can be mirrored onto your desktop as a fence enabling quick access to their contents without adding clutter to your desktop. To reveal your fence, you can move your mouse over the title-bar or double-click it again to view all of the icons as normal.įences can act as a portal to any folder on your PC. Save time and be more productive by creating folder portals to make accessing frequently used content only a Peek away.Įliminate clutter from your desktop, but keep your fences where it’s easy to find them with our roll-up feature! Double-clicking on a fence’s title-bar will “roll up” the rest of the fence into it, saving you valuable space on your desktop. Instantly access your files, folders, and applications with Peek by pressing Winkey + Space to bring your fences on top of all your windows. Fences has many customization features that make it the world’s most popular desktop enhancement. Organize your PC by automatically placing your shortcuts and icons into resizable shaded areas on your desktop called fences that are designed to match Windows 10 and 11. Designed to match Windows 10 and Windows 11 themesĪutomatically organize your desktop apps, files, and folders.Define rules to organize your desktop icons.Roll up fences to the Title-bar for cleaner desktops.Peek brings your fences on top for instant access. ![]() Create shaded areas to organize your desktop.Its many customization features are what make Fences the world's most popular Windows desktop enhancement. Fences helps you organize your PC by automatically placing your shortcuts and icons into resizable shaded areas on your desktop called fences. Zmatrix by evl9/19/2023
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